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Study 05: Macular Carotenoid Supplementation

Exp Eye Res. 2012 Aug;101:9-15. doi: 10.1016/j.exer.2012.05.006. Epub 2012 May 28.
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment.

Abstract
This study was designed to investigate the impact of macular carotenoid supplementation on the spatial profile of macular pigment (MP) in subjects where the profile does not exhibit the typical central peak (i.e. peaked MP at foveal epicentre).

Thirty one healthy subjects with such atypical MP spatial profiles were assigned to one of three intervention groups: Group 1: (n = 10), 20 mg/day lutein (L), 2 mg/day zeaxanthin (Z); Group 2: (n = 10), 10 mg/day meso-zeaxanthin (MZ), 10 mg/day L, 2 mg/day Z; Group 3: (n = 10), 17 mg/day MZ, 3 mg/day L, 2 mg/day Z. Subjects were instructed to take one capsule daily over an 8-week period. MP at 0.25°, 0.5°, 1°, 1.75° and 3° was measured using customized-heterochromatic flicker photometry at baseline, four weeks and 8 weeks.

Over the study period, we report no statistically significant increase in MP at any eccentricity in Group 1 (p > 0.05, for all eccentricities). There was a trend towards an increase in MP at all eccentricities in Group 2, with a significant increase found at 0.25° and 0.50° (p = 0.000 and p = 0.016, respectively).

There was a statistically significant increase evident in MP at 0.25° in Group 3 (p = 0.005), but at no other eccentricity (p > 0.05, for all other). We report that the typical central peak of MP can be realised in subjects with atypical spatial profiles, following supplementation with a preparation containing all three macular carotenoids, but not with a supplement lacking MZ. The implications of our findings, in terms of visual performance and/or a (photo)-protective effect, warrant additional study.

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Advanced AMD Support

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Dry Eyes Hydro

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Eyestrain Protect

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Products Based on Science

Check the studies that back our claims, ingredients and formulation. Open and transparent. 

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Study 01 - Lutein & Zeaxanthin

Lutein and zeaxanthin in the eyes, serum and diet of human subjects.

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Study 04: Measurement Of Ocular Blood Flow

Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration

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Study 02: A One Year Study of the Macular Pigment

A One Year Study of the Macular Pigment: The Effect of 140 Days of a Lutein Supplement.

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Study 05: Macular Carotenoid Supplementation

Macular carotenoid supplementation in
subjects with atypical spatial profiles
of macular pigment.

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Study 03: Placebo-Controlled Study Of Zeaxanthin

Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function...

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Study 06: Supplementation With 3 Macular Carotenoids

Supplementation with all three
macular carotenoids: response,
stability, and safety.

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EyesightLabs™ provides premium nutritional supplements for your eyesight and health. We believe that supplements should benefit your health without negative side-effects. Learn more about the science that supports our formulas.

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*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
The information on the website doesn't constitute a doctor-patient relationship. It for educational purposes only. Be sure to consult your duly licensed
physician before taking any supplements. Consult your doctor regarding any interactions with your health problems.