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Study 06: Supplementation With All Three Macular Carotenoids

Invest Ophthalmol Vis Sci. 2011 Nov 29;52(12):9207-17. doi: 10.1167/iovs.11-8025.
Supplementation with all three macular carotenoids: response, stability, and safety.

Abstract

PURPOSE:
This study was designed to investigate serum and macular response to, and safety of supplementation with, meso-zeaxanthin (MZ), lutein (L), and zeaxanthin (Z), the carotenoids that constitute macular pigment (MP).

METHODS:
Forty-four healthy subjects were recruited into this randomized, placebo-controlled, clinical trial. Subjects consumed one tablet per day containing 10.6 mg MZ, 5.9 mg L, and 1.2 mg Z (intervention, I group) or placebo (P group). The spatial profile of MP optical density (MPOD) was measured with customized heterochromatic flicker photometry (cHFP), and serum concentrations of L and Z were quantified by using high performance liquid chromatography (HPLC). Subjects were assessed at baseline and at 3 and 6 months. Clinical pathology analysis was performed at baseline and 6 months.

RESULTS:
Serum concentrations of L and Z increased significantly in the I group (P = 0.001 and 0.003, respectively) and remained stable in the P group (P > 0.05). There was a significant increase in central MPOD in the I group (0.25°: P = 0.001; 0.5°: P = 0.001), with no significant change in the P group (P > 0.05). Clinical pathology analysis confirmed that all variables remained within the normal reference range, with the exception of total cholesterol and low-density lipoprotein (LDL), which exhibited baseline values outside the accepted normal reference range before supplementation.

CONCLUSIONS:
Subjects supplemented with MZ, L, and Z exhibited significant increases in serum concentrations of these carotenoids and a subsequent increase in central MPOD. Pathology analysis suggested no adverse clinical implications of consuming these carotenoids. (http://isrctn.org number, ISRCTN60816411).

Featured Products

Advanced AMD Support

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Dry Eyes Hydro

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Eyestrain Protect

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Powerful support for your macular to protect from degeneration. Promotes better sight in sunlight.*

Products Based on Science

Check the studies that back our claims, ingredients and formulation. Open and transparent. 

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Study 01 - Lutein & Zeaxanthin

Lutein and zeaxanthin in the eyes, serum and diet of human subjects.

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Study 04: Measurement Of Ocular Blood Flow

Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration

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Study 02: A One Year Study of the Macular Pigment

A One Year Study of the Macular Pigment: The Effect of 140 Days of a Lutein Supplement.

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Study 05: Macular Carotenoid Supplementation

Macular carotenoid supplementation in
subjects with atypical spatial profiles
of macular pigment.

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Study 03: Placebo-Controlled Study Of Zeaxanthin

Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function...

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Study 06: Supplementation With 3 Macular Carotenoids

Supplementation with all three
macular carotenoids: response,
stability, and safety.

About Us:

EyesightLabs™ provides premium nutritional supplements for your eyesight and health. We believe that supplements should benefit your health without negative side-effects. Learn more about the science that supports our formulas.

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*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
The information on the website doesn't constitute a doctor-patient relationship. It for educational purposes only. Be sure to consult your duly licensed
physician before taking any supplements. Consult your doctor regarding any interactions with your health problems.